Drug–drug interaction analysis: Antituberculosis drugs versus antiretroviral drugs
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چکیده
منابع مشابه
Antituberculosis drugs and hepatotoxicity.
Isoniazid, pyrazinamide and rifampicin have hepatotoxic potential, and can lead to such reactions during antituberculosis chemotherapy. Most of the hepatotoxic reactions are dose-related; some are, however, caused by drug hypersensitivity. The immunogenetics of antituberculosis drug-induced hepatotoxicity, especially inclusive of acetylaor phenotype polymorphism, have been increasingly unravell...
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Currently, there are about 37 million people worldwide living with human immunodeficiency virus (HIV) /AIDS, with an estimated two million new cases per year globally. According to estimates from the World Health Organization (WHO), only 75% of the population with HIV know their status. Initially, HIV infection was associated with significantly increased rates of mortality and morbidity. Howeve...
متن کاملComparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated the effects of 30 anti-TB drugs, novel candidates, macrolides, and representative antiretroviral drugs on h...
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Delamanid is a medicinal product approved for treatment of multidrug-resistant tuberculosis. Three studies were conducted to evaluate the potential drug-drug interactions between delamanid and antiretroviral drugs, including ritonavir, a strong inhibitor of CYP3A4, and selected anti-TB drugs, including rifampin, a strong inducer of cytochrome P450 (CYP) isozymes. Multiple-dose studies were cond...
متن کاملStability of antituberculosis drugs mixed in food.
5. Mandell DL, Wald ER, Michaels MG, Dohar JE. Management of nontuberculous mycobacterial cervical lymphadenitis. Arch Otolaryngol Head Neck Surg 2003; 129:341–4. 6. Gerrits JA, Wolfs TF, Geelen SP. Three toddlers with a swelling in the neck [in Dutch]. Ned Tijdschr Geneeskd 2003; 147:225–9. 7. Lindeboom JA, Kuijper EJ, Bruijnesteijn van Coppenraet ES, R. Lindeboom, Prins JM. Surgical excision ...
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ژورنال
عنوان ژورنال: Biomedical and Biotechnology Research Journal (BBRJ)
سال: 2019
ISSN: 2588-9834
DOI: 10.4103/bbrj.bbrj_52_19